临床神经外科杂志2011，Vol.8Issue(3)：146-149,4.DOI:10.3969/j.issn.1672-7770.2011.03.011
三叉神经根区周围蛛网膜粘连与HSV-1感染关系的实验研究
Study on relationship between arachnoid adhesions around trigeminal nerve root zone and HSV-1 infection
胡庆雷 1陈剑 2孙彦春 1种衍军2
作者信息
- 1. 250001,济南,山东省医学科学院
- 2. 济宁市第一人民医院神经外二科
- 折叠
摘要
Abstract
Objective To study the relationship between arachnoid adhesions around trigeminal nerve root zone and Herpes simplex virus-1 ( HSV-1) infection. Methods A total of 40 cases of adhesion of arachnoid were taken from the trigeminal nerve root zone when operated to those patients with trigeminal neuralgia as experimental group. Another 20 cases of arachnoid were taken from craniocerebral injury patients as control. Each case was to do pathological section , at the same time to detect the DNA and antigen of HSV-1. Results The pathological changes in experimental group mainly appeared as inflammatory cell infiltration, edema and degeneration. The positive rate of HSV-1 gene was 72. 5％ , and the HSV-1 antigen positive rate was 17. 5％ . There were 3 cases with mild edema in control group, the rest were normal. 4 caese of HSV-1 gene were deteced, and no HSV- 1 antigen was found in control group. There was a significent difference of HSV-1 infection rate between experimental group and control group ( P ＜0. 05 ). Conclusions There is a close relationship between arachnoid adhesions around trigeminal nerve root zone and HSV-1 infection.Arachnoid adhesions wrapping arterial and trigeminal nerve which increased pressure on the trigeminal nerve, aggravate trigeminal neuralgia.关键词
三叉神经痛/蛛网膜/单纯疱疹病毒Ⅰ型/潜伏感染Key words
trigeminal neuralgia/ arachnoid/ Herpes simplex virus-1 / latent infection分类
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胡庆雷,陈剑,孙彦春,种衍军..三叉神经根区周围蛛网膜粘连与HSV-1感染关系的实验研究[J].临床神经外科杂志,2011,8(3):146-149,4.
