中南大学学报（自然科学版）2011，Vol.42Issue(5)：1232-1237,6.
纳米羟基磷灰石/壳聚糖载药微球的制备及性能
Preparation and performance of drug-loaded nano-hydroxyapatite/chitosan microspheres
摘要
Abstract
Nano-hydroxyapatite and chitosan were selected as matrix to prepare a novel metronidazole sustained release microsphere for bone tissue recovery. Aciform nano-hydroxyapatite was synthesized in ethanol medium (pH=11) using polyacrylic acid as dispersant. Metronidazole-loaded chitosan/hydroxyapatite composite microspheres were prepared by water in oil emulsion cross-linking method. The results show that the size of as-fabricated composite microspheres is mainly distributed from 1 to 10 μm, and hydroxyapatite and metronidazole are embedded very well by chitosan. The average drug loading is 38.23％, the average entrapment efficiency is 54.21％, and the cumulative release rate to metronidazole is near 82％ during 3 d. The composite microspheres are spherical and distributed uniformly in diameter with a good property for the slow-release of metronidazole, which have great potential in drug delivery system.关键词
缓释微球/甲硝唑/纳米羟基磷灰石/壳聚糖分类
医药卫生引用本文复制引用
李湘南,陈晓明,彭志明,李世普..纳米羟基磷灰石/壳聚糖载药微球的制备及性能[J].中南大学学报（自然科学版）,2011,42(5):1232-1237,6.基金项目
国家自然科学基金资助项目(50872099) （50872099）
