首页|期刊导航|中国神经再生研究（英文版）|Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis
中国神经再生研究（英文版）2011，Vol.6Issue(15)：1151-1157,7.DOI:10.3969/j.issn.1673-5374.2011.15.006
Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis
Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis
摘要
Abstract
This study investigated the effects of Yishendaluo decoction on the loss of blood-brain barrier integrity in mice exhibiting experimental autoimmune encephalomyelitis.To this end,we used real-time fluorescent quantitative PCR to measure the levels of mRNAs specific to the T cell markers CD4 and CD8,and the monocyte marker CD11b.In addition,we used Evans blue dye extravasation in the spinal cord and brain tissues to assess blood-brain barrier permeability.The results indicated that an increase in blood-brain barrier permeability was associated with an increase in CD4,CD8 and CD11b mRNA expression in experimental autoimmune encephalomyelitis mice.Yishendaluo decoction administration significantly reversed inflammatory cell accumulation in cerebral tissues of experimental autoimmune encephalomyelitis mice.关键词
experimental autoimmune encephalomyelitis/Yishendaluo decoction/blood-brain barrier/neurological score/spinal cordKey words
experimental autoimmune encephalomyelitis/Yishendaluo decoction/blood-brain barrier/neurological score/spinal cord引用本文复制引用
Yanqing Wu,Ying Gao,Lingqun Zhu,Yonghong Gao,Dongmei Zhang,Lixia Lou,Yanfang Yan..Effects of Yishendaluo decoction on blood-brain barrier integrity in mice with experimental autoimmune encephalomyelitis[J].中国神经再生研究（英文版）,2011,6(15):1151-1157,7.基金项目
the National Natural Science Foundation of China (Effects and mechanisms of Yishendaluo decoction on tissue damage subjected to experimental autoimmune encephalomyelitis),No.30672692. （Effects and mechanisms of Yishendaluo decoction on tissue damage subjected to experimental autoimmune encephalomyelitis）
