中国中医药信息杂志2011，Vol.18Issue(5)：35-37,3.DOI:10.3969/j.issn.1005-5304.2011.05.013
聚乙二醇化环维黄杨星D对大鼠长期给药肝、肾毒性研究
Toxicity Study in Liver and Kidney After Long-term Intravenous Injection of PEGylated Cyclovirobuxine D
摘要
Abstract
Objective To study the liver and kidney toxicities on rats after long-term intravenous injection of Cyclovirobuxine D and PEGylated Cyclovirobuxine D, and to investigate the effect of PEGylation in reducing the toxicity. Methods Fifty Sprague-Dawley rats were randomly divided into 5 groups (10 in each group): the control group, the Cyclovirobuxine D group, the high-, middle- and low-dose groups of PEGylated Cyclovirobuxine D. Body weight, serum biochemical parameters and pathological examination in liver and kidney tissue were examined after intravenous injection of different dosages of Cyclovirobuxine D and PEGylated CyclovirobuxineD for 28 days. Results Blood uric acid level in Cyclovirobuxine D group was much higher than that in control group; there wasn't difference between the PEGylated Cyclovirobuxine D groups and the control group. It suggested that renal function might be affected in Cyclovirobuxine D group. Liver tissue of Cyclovirobuxine D group and PEGylated Cyclovirobuxine D group had pathological change. Liver toxicity of the Cyclovirobuxine D group was higher than that of the PEGylated Cyclovirobuxine D group at the same dose. Conclusion PEGylated Cyclovirobuxine D has lower liver and kidney toxicities than Cyclovirobuxine D.关键词
聚乙二醇化环维黄杨星D/环维黄杨星D/长期毒性实验/大鼠分类
医药卫生引用本文复制引用
徐立华,马永婷,邢精红,赵宣,梁涛,黄文哲..聚乙二醇化环维黄杨星D对大鼠长期给药肝、肾毒性研究[J].中国中医药信息杂志,2011,18(5):35-37,3.基金项目
北京市科技计划研发攻关类课题(Z090502008909010) （Z090502008909010）
