首页|期刊导航|中国神经再生研究（英文版）|Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice
中国神经再生研究（英文版）2011，Vol.6Issue(9)：645-650,6.DOI:10.3969/j.issn.1673-5374.2011.09.001
Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice
Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice
摘要
Abstract
Huanglian Jiedu decoction (HLJDD) has been shown to improve cerebral blood flow, and reduce lipid peroxidation damage to the brain and its energy metabolism. The present study was designed to observe the cerebroprotective effect of HLJDD on an Alzheimer's disease rodent model,presenilin-1/amyloid protein precursor double transgenic mice. HLJDD reduced serum interleukin-6 and interleukin-1β levels, decreased β-amyloid precursor protein gene and senile plaque expression, resisted oxidation, and reduced free radical-induced injury, thereby improving the learning and memory of these mice. Moreover, HLJDD at 433 mg/kg per day exhibited better effects compared with that at 865 or 216 mg/kg per day, and donepezil hydrochloride at 30 mg/kg per day.Thus, these results suggest that HLJDD may have protective effects against Alzheimer's disease.关键词
Huanglian Jiedu decoction/amyloid protein precursorlpresenilin-1 double transgenic mice/effect/hippocampus/neural regenerationKey words
Huanglian Jiedu decoction/amyloid protein precursorlpresenilin-1 double transgenic mice/effect/hippocampus/neural regeneration引用本文复制引用
Xin Qiu,Guohua Chen,Gui Mei,Yuegu Wang,Kaixin Wang,Tao Wang,Pei Feng..Cerebroprotective effect of Huanglian Jiedu decoction on amyloid protein precursor/presenilin-1 double transgenic mice[J].中国神经再生研究（英文版）,2011,6(9):645-650,6.基金项目
the Natural Science Foundation of Hubei Province,No.2007ABA060 （）
