中国神经再生研究（英文版）2011，Vol.6Issue(9)：661-665,5.DOI:10.3969/j.issn.1673-5374.2011.09.004
Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model
Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model
Gang Yao 1Yuhong Man 1Jingjing Qi 1Tingmin Yu 1Dihui Ma1
作者信息
摘要
Abstract
Toutongning capsule is used for the treatment of migraine headaches, and has yielded therapeutically beneficial effects. However, whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood. This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels. Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule. The numbers of methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group. Taken together, these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats.关键词
proenkephalin/methionine-enkephalin/leucine-enkephalin/migraine headache/Toutongning capsule/neural regenerationKey words
proenkephalin/methionine-enkephalin/leucine-enkephalin/migraine headache/Toutongning capsule/neural regeneration引用本文复制引用
Gang Yao,Yuhong Man,Jingjing Qi,Tingmin Yu,Dihui Ma..Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model[J].中国神经再生研究（英文版）,2011,6(9):661-665,5.
