中药材2011，Vol.34Issue(4)：567-572,6.
原儿茶酸对新生大鼠皮质神经元存活及突起生长的影响
Neurotrophic Effects of Protocatechuic Acid on Neurite Outgrowth and Survival in Cultured Cerebral Cortical Neurons of Newborn Rat
摘要
Abstract
Objective: To study the neurotrophic effects of protocatechuic acid on neurite outgrowth and survival in cultured cerebral cortical neurons. Methods: The newborn rat cerebral cortex neurons were cultured in vitro. The convert phase microscope was used to count the survival neurons with neurites and measure the average length of neurites. MTT and LDH assay were carried out to investigate the effect of PCA on the neuronal viability. Results: Compared with control group, different concentration of PCA could increase the number of survival neurons with neurites and the average length of neurites. MTT and LDH assay showed that PCA promoted neuron survival in a dose-dependent manner. Conclusion:PCA can enhance the survival of rat cortical neurons with neurites and promote the neurite outgrowth of rat cortical neurons.关键词
原儿茶酸/大鼠皮质神经元/神经营养作用Key words
Protocatechuic acid/Cerebral cortex neuron/Neurotrophic effects分类
医药卫生引用本文复制引用
薛小燕,林炼峰,肖飞,皮婷,赖永长,罗焕敏..原儿茶酸对新生大鼠皮质神经元存活及突起生长的影响[J].中药材,2011,34(4):567-572,6.基金项目
国家"211工程"建设经费资助. （）
