中国药理学通报2011，Vol.27Issue(7)：1015-1018,4.DOI:10.3969/j.issn.1001-1978.2011.07.029
虫草头孢菌粉水提物抗实验性心律失常作用的研究
Experimental studies on antiarrhythmic effect of cordyceps cephalosporium mycelia extracts
摘要
Abstract
Aim To investigate the antiarrhythmic effect of Cordyceps Cephalosporium Mycelia ( CCM ) extracts. Methods The conventional antiarrhythmic methods were used. Arrhythmia was induced by chloroform in mice. The intravenous injection of aconitine and coronary artery ligation method were perforred to induce arrhythmia in rat model, which were given CCM extraction in preoperation. Electrocardiogram currve was recorded and analysed. Results Administration of CCM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice. CCM significantly prolonged the onset of arrhythmia induced by aconitine in rats. Compared with control, arrhythmia score was lower in ischemia/reperfusion rats pretreated with CCM extracts.Conclusion CCM extracts has obvious protective effects on chloroform, conitine- and ischemia-reperfusion induced arrhythmia.关键词
虫草头孢菌粉/心律失常/氯仿/乌头碱/缺血/再灌注损伤分类
医药卫生引用本文复制引用
姚红伊,沈礼,林国华,沈岳良,王如伟,谢强敏,颜小锋..虫草头孢菌粉水提物抗实验性心律失常作用的研究[J].中国药理学通报,2011,27(7):1015-1018,4.基金项目
国家自然科学基金资助项目(No 30772581) （No 30772581）
浙江省科技厅重点科技攻关项目(No 2007C23022) （No 2007C23022）
