中国临床药理学与治疗学2011，Vol.16Issue(3)：317-321,5.
血管紧张素转化酶抑制剂加钙离子拮抗剂联合用药治疗模式对于轻、中度原发性高血压的临床疗效观察及其对血尿酸水平的影响
Clinical investigation of ACE inhibitor combined with calcium antagonist on the patients with mild to moderate essential hypertension and it's effect on the serum uric acid level
伍艳1
作者信息
- 1. 望城县人民医院药剂科,望城410200,湖南
- 折叠
摘要
Abstract
AIM: To compare the clinical effect of combination of captopri with amlodipine and monotherapy of amlodipine, and the influence on the serum uric acid level. METHODS:80 patients with mild to moderate essential hypertension were selected and divided into two groups. 40 patients of the study group were treated with captopri (25 mg/capsule, bid) and amlodipine (5 mg, q. d. ) for 8 weeks, 40 patients of the control group were treated with amlodipin (5 mg, q. d. ) for 8 weeks. The efficacy of both groups was evaluated by comparing the variance of blood pressure and serum uric acid.RESULTS.. The blood pressure of the combined therapy was decreased from (98± 7) mm Hg to (92±8) mm Hg after 4 weeks and to (86±11) mm Hg after 8 weeks, the difference is statistically significant (P＜0.05). The blood pressure of the monotherapy group was (96±8) mm Hg,which is not statistically significant different from (95±7) mm Hg after 4 weeks. The blood pressure of the monotherapy group was (90±8) mmHg after 8 weeks, which is significantly different from (96±8) mm Hg (P＜0.05). The decreased extent of the combined therapy group was significantly different from the monotherapy group. The serum uric acid of the two groups were decreased and the decreased extent of the combined therapy was significant than that of monotherapy group. CONCLUSION.. The combined therapy for the mild to moderate essential hypertension is an effective strategy and can protect the organ.关键词
血管紧张素转化酶抑制剂/钙离子拮抗剂/高血压/临床疗效/血尿酸Key words
ACE inhibitor/ Calcium antagonist/ Hypertension/ Effect/ Serum uric acid分类
医药卫生引用本文复制引用
伍艳..血管紧张素转化酶抑制剂加钙离子拮抗剂联合用药治疗模式对于轻、中度原发性高血压的临床疗效观察及其对血尿酸水平的影响[J].中国临床药理学与治疗学,2011,16(3):317-321,5.
