陕西医学杂志2011，Vol.40Issue(6)：656-657,663,3.
5,7-双羟色胺损毁大鼠中缝背核对内侧前额叶皮层锥体神经元电活动的影响
Increase of neuronal activity of the pyramidal neurons in mPFC after lesioning in the dorsal raphe nucleus by 5,7-dihydroxytryptamine in adult rats
摘要
Abstract
Objective : To study the neuronal activity of pyramidal neurons in medial prefrontal cortex (mPFC) after lesioning in the dorsal raphe nucleus by 5, 7-dihydroxytryptamine in adult rats.Methods : The change of the spontaneous firing of pyramidal neurons in mPFC after lesioned by 5, 7-DHT was observed by extracellular recording in vivo.Results : The firing rate of pyramidal neurons in mPFC increased significantly from (0.52±0.10) Hz to (1.25±0.20) Hz (P＜0.001), and the firing pattern of these neurons changed significantly to a more burstlng firing (P＜0.001).Conclusion : Neuronal activity of the mPFC pyramidal neurons significantly increases after lesioning of the dorsal raphe nucleus by 5,7-dihydroxytryptamine in adult rats.关键词
5,7-二羟色胺/额叶前皮层/锥体细胞/电生理学过程分类
医药卫生引用本文复制引用
王爽,高捷,苏兴利,郭玉芳,霍健,王湘,曾文..5,7-双羟色胺损毁大鼠中缝背核对内侧前额叶皮层锥体神经元电活动的影响[J].陕西医学杂志,2011,40(6):656-657,663,3.基金项目
陕西省卫生厅科研基金资助项目(2010D57) （2010D57）
