中国药理学与毒理学杂志2011，Vol.25Issue(3)：314-319,6.DOI:10.3867/j.issn.1000-3002.2011.03.019
印迹壳低聚糖在小鼠体内的代谢与组织分布
Metabolism and distribution of imprinted chitooligosaccharides in mice
张晓菲 1刘丽宏 2丁春雷 2杨润涛 2赵长琦2
作者信息
- 1. 北京师范大学生命科学学院,北京,100875
- 2. 中国人民解放军第二炮兵总医院药剂科,北京,100088
- 折叠
摘要
Abstract
OBJECTIVE To explore the metabolism and distribution of imprinted chitooligosaccharides (CTS) in mice. METHODS CTS were labeled by fluorescein isothiocyanate (FITC) before FITC-CTS 100 mg·kg-1 were iv given to mice. At 10 min, 0.5, 1,4, 8, 12, 24 and48 h after administration, serum and urine samples were collected and FITC-CTS were detected by fluorospectrophotometer and high performance gel permeation chromatography (HPGPC). RESULTS FITC-CTS was metabolized fast from plasma, and FITC-CTS concentration declined by 68％ at 4 h. Sixty percentage FITC-CTS were distributed in kidneys, 30％ in the liver, and hardly distributed in other organs. Ninty percentage FITC-CTS were excreted from urine in its original form after 24 h. CONCLUSTION CTS are low biodegradable, mainly distribute in kidneys and liver, and totally excrete from urine in original form.关键词
壳低聚糖/代谢/组织分布分类
医药卫生引用本文复制引用
张晓菲,刘丽宏,丁春雷,杨润涛,赵长琦..印迹壳低聚糖在小鼠体内的代谢与组织分布[J].中国药理学与毒理学杂志,2011,25(3):314-319,6.
