分析化学2011，Vol.39Issue(3)：432-438,7.DOI:10.3724/SP.J.1096.2011.00432
传感器表面的适配体固定方法及其在生物传感器中的研究进展
Application of Biosensor Surface Immobilization Methods for Aptamers
摘要
Abstract
Aptamer with small molecular weight, simple structure and easy synthesis, repeatable usage and long-term preservation, has important applications in biosensor field. Several common used methods for aptamer fixed onto the sensor surface were introduced in this view, including the goldsulfur self-assembled monolayers, covalent bond, biotin/avidin affinity, complementary nucleic acid chain connection, as well as current research progress and the characteristics of each method. The wide detection range, low detection limit, short detection time and multi-detection will be the development trend and emphasis for aptasensors used in food quality and safety testing, disease diagnosis, drug analysis, environment monitoring , etc.关键词
适配体/生物传感器/固定方法/评述Key words
Aptamers/ Biosensors/ Fixation methods/ Review引用本文复制引用
周玲,王明华,王剑平,叶尊忠..传感器表面的适配体固定方法及其在生物传感器中的研究进展[J].分析化学,2011,39(3):432-438,7.基金项目
本文系国家自然科学基金(No.2097041)资助项目 （No.2097041）
