色谱2011，Vol.29Issue(3)：217-222,6.DOI:10.3724/SP.J.1123.2011.00217
高效液相色谱-串联质谱法测定猪肉中的阿维菌素类、地克珠利、妥曲珠利及其代谢物残留
Determination of avermectin,diclazuril,toltrazuril and metabolite residues in pork by high performance liquid chromatography-tandem mass spectrometry
摘要
Abstract
A method for the determination of avermectin, ivermectin, doramectin, moxidectin,eprinomectin, diclazuril, toltrazuril and its two metabolite residues in pork was developed using QuEChERS method with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The sample was extracted with acetonitrile and purified through QuEChERS method using ODS as the sorbent. The target compounds were separated on a Venusil ASB C18 column (150 mm ×2. 1 mm, 3.0 μm) and detected by HPLC-MS/MS. The linear ranges were 0.005 -0.2 mg/L and the correlation coefficients were all above 0. 990. The average recoveries and the relative standard deviations ranged from 73.2％ to 91.5％ and from 12％ to 17％ at the spiked levels of 0.005,0.01 and 0.02 mg/kg for the 9 analytes in pork matrix. This method is reliable, and suitable for the determination of the residues of avermectin and related compounds in pork.关键词
高效液相色谱-串联质谱/阿维菌素类药物/地克珠利/妥曲珠利及其代谢物/猪肉Key words
high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)/ avermectin/ diclazuril/ toltrazuril and its metabolites/ pork分类
化学化工引用本文复制引用
宫小明,孙军,董静,于金玲,王洪涛..高效液相色谱-串联质谱法测定猪肉中的阿维菌素类、地克珠利、妥曲珠利及其代谢物残留[J].色谱,2011,29(3):217-222,6.基金项目
山东检验检疫局科研基金项目(项目编号:SK201028). （项目编号:SK201028）
