中国药理学与毒理学杂志2011，Vol.25Issue(3)：240-244,5.DOI:10.3867/j.issn.1000-3002.2011.03.004
格拉司琼对咯利普兰致呕吐、抗抑郁及增强学习记忆能力的影响
Effects of granisetron on vomiting, anti-depression and memory enhancement potential of rolipram
摘要
Abstract
OBJECTIVE To assess the anti-emetic potential of granisetron(Gra) on mice vomiting induced by rolipram(Rol) and the effect of Gra on anti-depression and spatial memory enhancement of Rol.METHODS The anti-emetic potential of Gra was evaluated based on the duration of anesthesia in mice induced by the combination of xylazine/ketamine, which was determined as the time between the loss and regaining of the righting reflex.The depression models ( forced swimming test and tail suspension test ) and Morris water maze were used to assess the anti-depression and cognitive enhancement effects with the combination of Gra and Rol.RESULTS Rol 0.5 mg·kg-1 significantly reduced duration of anesthesia induced by xylazine/ketamine in KM mice from (48.6 ± 11.1)minto (30.0±8.6)min (P＜0.05).Then Rol combined with Gra0.05, 0.5 and5 mg·kg-1 increased the duration of anesthesia compared with Rol as (39.5 ±15.5)min, (43.1 ± 17.7 ) min ( P ＜ 0.05 ) and (42.1 ± 16.6 ) min ( P ＜ 0.05 ).Forced swimming test and tail suspension test data showed Rol combined with Gra did not influence the immobility time.Meanwhile, Rol combined with Gra did not influence spatial memory performance in Morris water maze.CONCLUSION Rol combined with Gra can significantly reduce the emetic potential of Rol, without intervention in its antidepressant effects or cognitive enhancement.So the combination of Rol and Gra is a potential effective treatment for nausea and vomiting in pharmacodynamics.关键词
咯利普兰/格拉司琼/恶心呕吐/抗抑郁/学习记忆/联合用药分类
医药卫生引用本文复制引用
李国熊,周涛,周恒,许重远,徐江平..格拉司琼对咯利普兰致呕吐、抗抑郁及增强学习记忆能力的影响[J].中国药理学与毒理学杂志,2011,25(3):240-244,5.基金项目
国家自然科学基金资助项目(30672453) （30672453）
国家自然科学基金资助项目(30973518) （30973518）
