医药导报2011，Vol.30Issue(7)：877-879,3.DOI:10.3870/yydb.2011.07.014
独一味环烯醚萜苷外用止血作用研究
Hemostatic Effects of Externally Application of the Effective Components from Herba Lamiophlomis Rotata
张泉龙 1邱建国 1李茂星 1尉丽力 1何希瑞 1贾正平1
作者信息
- 1. 兰州军区总医院药材科,全军高原环境损伤防治重点实验室,兰州,730050
- 折叠
摘要
Abstract
Objective To study the external hemostatic effect of the components from Herba Lamiophlomis Rotata.Methods The mouse tail-cutting model, abdominal aorta incision, ears artery cutting in rabbits and the experimental model of superficial cut of liver in SD adult rats, were used to evaluate and compare the hemostatic effect by starch, yunnan baiyao powder, L. rotata aqueous extract ( LRAE) and the iridoid glycosides extract of L. rotata (IGLR). Results In the tail cut mice model, the bleeding time for IGLR, LRAE, yunnan baiyao powder and starch groups were ( 64. 8±25.0) , (97. 2±44.0) ,( 105. 1±65.0) , ( 124. 8±43. 2) s, respectively. The average bleeding duration of superficial cut of liver for IGLR group was (93. 8±39.5) s, ( 101. 1±25. 9) s for LRAE, ( 74. 0±26. 3) s for yunnan baiyao powder and ( 152. 8±47. 1) s for starch control. The IGIR group had significantly lower bleeding time than the placebo group in the abdominal aorta incision model and ears artery model ( P＜0. 01) , which was stronger than yunnan baiyao powder ( P＜0. 05 or P＜0. 01) . Likewise , the LRAE group showed significantly shorter bleeding time than the placebo group( P＜0. 01) , but was longer than IGIR group. Conclusion Herba Lamioplzlomis Rotata. provides hemostatic effects being applied externally, which is better than LRAE and yunnan baiyao powder.关键词
独一味/总环烯醚萜苷/止血作用Key words
Herba Lamiophlomis Rotata. /Iridoid glycosides/ Hemostatic effect分类
医药卫生引用本文复制引用
张泉龙,邱建国,李茂星,尉丽力,何希瑞,贾正平..独一味环烯醚萜苷外用止血作用研究[J].医药导报,2011,30(7):877-879,3.
