安徽医科大学学报2011，Vol.46Issue(5)：475-477,3.
高迁移率族蛋白1与肿瘤细胞凋亡
Serum levels of OPN and TGFβ1 in adults with difficult-to-treat asthma
沈磊1
作者信息
- 1. 安徽医科大学免疫学教研室,合肥,230032
- 折叠
摘要
Abstract
Objective To detect serum levels of OPN and TGFβ1 in adult with difficult-to-treat asthma and to investigate their roles in difficult-to-treat asthma. Methods Serum levels of OPN,TGFβ1 were detected by ELAISA in 29 asthmatic adults with difficult-to-treat and 20 asthmatic adults without difficult-to-treat ,20 healthy adults served as control group. Results Compared with the without difficult-to-treat asthma group and control group,serum OPN levels were significantly higher( P ＜ 0. 05 ), but serum TGFβ1 levels were significantly lower in difficult-to-treat asthma( P ＜ 0.05 ). Serum OPN levels were negatively correlated with serum TGFβ1 level in asthma. Conclusion There might be an imbalance in serum OPN, TGFβ1 levels in adults with difficult-to-treat asthma. The abnormal serum levels of OPN and TGFβ1 may be useful in the diagnosis and severity evaluation of difficult-to-treat asthma.关键词
肿瘤/自噬/细胞凋亡Key words
asthma/osteopontin/transforming growth factor betal分类
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沈磊..高迁移率族蛋白1与肿瘤细胞凋亡[J].安徽医科大学学报,2011,46(5):475-477,3.
