浙江医学2011，Vol.33Issue(6)：794-796,799,4.
鼻咽癌四野面颈联合野适形放疗技术及剂量学研究
Technical and dosimetric study of four facio-cervical fields conformal radiotherapy for nasopharyngeal carcinoma
摘要
Abstract
Objective To establish and optimize the methods of four- field conformal radiotherapy(4F- CRT) for nasopharyngeal carcinoma (NPC). Methods Forty patients with untreated NPC of Tl～T4 (1992 Fuzhou Staging System)were enrolled in this study. Conventional and four- field conform plans (improved plan) were designed for each patient using 3D- TPS. The improved plan included anterior facio- cervical and two lateral opposing facio- cervical fields; the conventional plan had two lateral opposing facio-cervical fields only. Both plans had the same dose delivered to the target of each patient. Dose volume histograms (DVHs)of the targets and normal organs, brain stem, spinalcord, parotid glands, and temporal mandibular joints (TMJs)were compared and the dose distributions were evaluated.Results The dose distribution of the improved plan met the requirements for the target volume. There was no significant difference in the dose of spinal cord between the two plans. The mean dose of Dmax for brain stem in conventional plan was much lower than those in the improved plan, though both were within safety limits. Compared with the conventional plans, the improved plan significantly decreased the hotspot areas in the target volume and had better parotid glands and temporal mandibular joints sparing effect.Conclusion Compared with the conventional plan, the improved plan provides satisfactory dose coverage to the target volume and better sparing of the parotid gland, TMJs and other normal organs in external beam radintherapy of NPC.关键词
鼻咽恶性肿瘤/四野适形放疗/剂量学Key words
Nasopharyngeal neoplasms/ Four-field conformal radiotherapy/ Dosimetry引用本文复制引用
王方正,付真富,王磊,朴永锋,花永虹,祝成龙,徐敏,陈伟军..鼻咽癌四野面颈联合野适形放疗技术及剂量学研究[J].浙江医学,2011,33(6):794-796,799,4.基金项目
浙江省卫生厅科研基金项目(2009B026) （2009B026）
