浙江医学2011，Vol.33Issue(6)：797-799,3.
尿脱氧吡啶啉检测在肺癌骨转移诊断与治疗评估中的意义
Detection of urinary deoxypyridinoline in diagnosis and treatment of osseous metastasis of lung cancer
卢丽琴 1袁国荣 1钦志泉 1赵同伟 1薛骞 1吴国清 1郑爱红 1高亮 1孙馨1
作者信息
- 1. 310014,杭州,浙江省人民医院肿瘤科
- 折叠
摘要
Abstract
Objective To evaluate the application of urinary deoxypyridinoline (uDPD) in diagnosis and treatment of osseous metastasis of lung cancer.Methods Urinary DPD was detected in 202 patients with lung carcinoma and the uDPD/Cr was compared between patients with or without osseous metastasis.Sensitivity and specificity of uDPD/Cr for diagnosis of osseous metastasis of lung cancer was calculated.Fifty patients with osseous metastasis were treated with pamidronate (n=25) or chemotherapy (n=30) for 2 weeks, and the uDPD/Cr value of 2 groups were tested and compared.Results The sensitivity and specificity of uDPD/Cr for diagnosis of osseous metastasis of lung cancer were 81.4％ and 70.0％ respectively.In pamidronate group the uDPD/Cr was (13.37± 2.65) nmol/ mmol and (7.34± 2.15)nmol/ mmol before and after treatment (P ＜0.01).in chemotherapy group uDPD/Cr was (12.85± 2.52)nmol/ mmol and (8.43± 2.63)nmol/ mmol before and after treatment (P＜0.05).Conclusion Detection of uDPD is ofvalue in diagnosis and assessment oftherapeutic effect in lung cancer with osseous metastasis.关键词
肺肿瘤/肿瘤转移/脱氧吡啶啉Key words
Lung neoplasms / Neoplasms metastasis / Deoxypryidinoline引用本文复制引用
卢丽琴,袁国荣,钦志泉,赵同伟,薛骞,吴国清,郑爱红,高亮,孙馨..尿脱氧吡啶啉检测在肺癌骨转移诊断与治疗评估中的意义[J].浙江医学,2011,33(6):797-799,3.
