武警医学2011，Vol.22Issue(3)：234-236,3.
盐酸米诺环素对慢性牙周炎基质金属蛋白酶-8水平的影响
Effect of Minocycline Hydrochloride Ointment on MMP-8 in Gingival Crevicular Fluid Abstract
井枫秋 1汪黎明 1张洁 1黄云亮1
作者信息
- 1. 200001,上海市口腔病防治院口腔内科
- 折叠
摘要
Abstract
Objective To analyze the changes of matrix metalloproteinases - 8 ( MMP - 8) levels in gingival crevicular fluid (GCF) after subgingivally administering 2％ minocycline - HCl ointment to the periodontal pocket as an auxiliary treatment of moderate and severe chronic periodontitis. Methods Twenty - six subjects were selected. The left and right sides of oral cavity were divided into control group and test group with a randomized single blind method. After initial periodontal treatment of both groups, the test group was treated with the sustained release unguent of minocycline - HCL ointment in the pocket once a week for 2 weeks,while the control group with 0.9 ％ normal saline and 10％ hydrogen peroxide. Two weeks later, gingival crevicular fluid samples were collected and detected with ELISA technique. Results The level of MMP - 8 in GCF obviously declined after treatment in both groups( P ＜0.01 ), particularly in the test group. The difference was statistically sigificant(P ＜ 0. 01 ). Conclusions Administration of the local drug system of 2％ minocycline - HCL ointment as the auxiliary treatment of moderate and severe chronic periodontitis can reduce the levels of matrix metalloproteinases -8 in GCF and improve the periodontal tissue conditions.关键词
盐酸米诺环素/基础治疗/龈沟液/基质金属蛋白酶-8Key words
minocycline- HCI ointment/ initial therapy/ gingival crevicular fliud/ matrix metalloproteinases- 8分类
医药卫生引用本文复制引用
井枫秋,汪黎明,张洁,黄云亮..盐酸米诺环素对慢性牙周炎基质金属蛋白酶-8水平的影响 [J].武警医学,2011,22(3):234-236,3.
