浙江医学2011，Vol.33Issue(6)：813-815,818,4.
应用SELDI-TOF-MS技术研究急性胰腺炎特异性血清标志物
Screening serum biomarkers by SELDI-TOF-MS in acute pancreatitis
摘要
Abstract
Objective To analyze the serum proteomic pattern in patients with acute pancreatitis by using surface- enhanced laser desorption/ionization time- of- flight mass spectrometry (SELDI- TOF- MS).Methods Serum samples were collected from 52 patients with acute pancreatitis, including 24 cases of severe acute pancreatitis (SAP), 28 cases of mild acute pancreatitis (MAP); 52 serum samples from healthy subjects were used as controls.The proteomic patterns of all serum samples were analyzed by SELDI- TOF- MS method.Results Five protein peaks were found related to acute pancreatitis, and there were three different protein peaks between MAP and SAP.Conclusion Proteomic technology may identify novel biomarkers in serum of patients with pancreatitis.关键词
急性胰腺炎/表面加温激光解析电离-飞行时间表-质谱术/血清蛋白指纹Key words
Acute pancreatitis / SELDI-TOF-MS / Serum proteomic patterns引用本文复制引用
尚敏杰,郦卫星,胡智明,赵大建,张成武,吴伟顶,张宇华,刘杰..应用SELDI-TOF-MS技术研究急性胰腺炎特异性血清标志物 [J].浙江医学,2011,33(6):813-815,818,4.基金项目
浙江省卫生厅科研基金资助项目(2007A007) （2007A007）
