农药学学报2011，Vol.13Issue(2)：121-126,6.DOI:10.3969/j.issn.1008-7303.2011.02.04
取代双吡唑类化合物的合成及杀虫活性
Synthesis and insecticidal activity of a series of novel substituted bipyrazole compounds
姬文娟 1许天明 2魏优昌 1姚巍 2邢家华 2谭成侠2
作者信息
- 1. 浙江工业大学化学工程与材料学院,杭州310014
- 2. 浙江省化工研究院,国家南方农药创制中心浙江基地,杭州310023
- 折叠
摘要
Abstract
1 - ( 3-chlorophenyl ) - 1H-pyrazole4-carbaldehyde ( 4 ) was synthesized with cyclization and Vilsmeier reaction using 1-( 3-chlorophenyl ) hydrazine hydrochloride ( 1 ) and 1, 1,3,3-tetramethoxypropane ( 2 ) as raw materials.Claisen-Schmidt reaction of ( 4 ) with 1-( 3-( trifluoromethyl )phenyl) ethanone ( 5 ) afforded substituted arylketenes ( 6 ).Then 3-( 3-trifluoromethylphenyl ) -5-( 3-chlorophenyl-1H-pyrazol)-4,5-dihydropyrazole ( 7 ) was obtained by cyclization of 6 with hydrazine hydrate from which 15 novel title compounds (ZJ1-15) were synthesized with isocyanates (8).The structures of the compounds were confirmed by MS and 1H NMR.The preliminary biological activity showed that the mortality ratio of some compounds against Plutella xylstella were 100％ at concentration of 500 mg/L.All the compounds possessed no insecticidal activities against Aphimedicaginis,Nilaparvata lugens or Tetranychus cinnabarinus.关键词
氰氟虫腙/双吡唑类化合物/合成/杀虫活性Key words
metaflumizone/ bipyrazoles compounds/ synthesis/ insectical bioactivity分类
化学化工引用本文复制引用
姬文娟,许天明,魏优昌,姚巍,邢家华,谭成侠..取代双吡唑类化合物的合成及杀虫活性[J].农药学学报,2011,13(2):121-126,6.
