摘要
Abstract
Objective To investigate the distribution, drug resistance and rational use of antibiotics in complicated bacterial urinary tract infection. Methods To retrospect the clinical data and results of drug susceptibility from 188 patients in our hospital with complicated urinary tract infection from 2004 to 2009. Results The Gram-negative bacilli ( 40. 4％Escherichia coli and 8. 5％ Klebsiella pneumoniae) accounted for 69. 1％ , Enterococcus faecalis 10. 6％ , Enterococci 7. 4％ ,coagulase-negative staphylococci 3. 7％ ,fungi 4. 3％ among the pathogens caused complicated urinary tract infection. ESBL positive rate in 76 cases of Escherichia coli was 48. 2％. The drug resistance to amoxicillin/clavulanic acid, cefoperazone/sulbactam , piperacillin/tazobactam , cefoxitin , amikacin, carbapenem, nitrofurantoin was low ; while the resistance to ampicillin ,piperacillin, cephalosporins, quinolones was high. Conclusion Escherichia coli is still the main pathogen for current complicated urinary tract infection in hospitals, the drug resistance of which is high and multiple, and is the most common bacterial strain producing ESBLs. The antimicrobial therapy should be adjusted under the guidance of drug sensitivity test.关键词
抗菌药物/感染,尿路,复杂性/致病菌分布/耐药性Key words
Antibiotics/lnfection, urinary tract, complicated/ Distribution of bacteria/ Drug resistance分类
医药卫生
