医学分子生物学杂志2011，Vol.8Issue(3)：194-197,4.DOI:10.3870/j.issn.1672-8009.2011.03.002
miR-125b在前列腺癌1E8细胞运动转移中的作用及其分子机制的初步探讨
Effects of MiR-125b on Cell Migration and Invasion in Prostate Cancer Cells
摘要
Abstract
Objective To investigate the differential expression of miR-125b in various prostate cancer cell lines and the effects of miR-125b on cell migration and invasion in prostate cancer. Methods The differential expression of miRNA in 1E8 ( high metastasis prostate cancer) and 2B4 ( low metastasis prostate cancer) cell lines were analyzed by real-time PCR. Cell migration and invasive ability were detected by Transwell experiment. Results The levels of miR-125b significantly increased, compared to 2B4 cells. The invasiveness of 1E8 cells were decreased when miR-125b was down-regulated. Conclusion miR-125b enhances invasiveness of prostate cancer cells.关键词
前列腺癌/miR-125b/microRNAKey words
prostate cancer/ miR-125b/ microRNA分类
医药卫生引用本文复制引用
孔繁飞,孙朝阳,王中显,吕煊,翁丹卉,卢运萍,陈刚,李科珍..miR-125b在前列腺癌1E8细胞运动转移中的作用及其分子机制的初步探讨[J].医学分子生物学杂志,2011,8(3):194-197,4.基金项目
国家重点基础研究发展规划项目(973计划)(No.2009CB521808),湖北省自然科学基金(No.2010cdb09403) （973计划）
