中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(6)：349-353,5.DOI:10.1007/s10330-011-0795-6
宫颈癌术后骨髓保护调强放疗研究
Bone marrow-sparing intensity-modulated radiotherapy for postoperative treatment of cervical cancer
Fuli Zhang 1Mingmin Zheng 1Junmao Gao 1Weidong Xu1
作者信息
摘要
Abstract
Objective: The aim of this study was to compare bone marrow-sparing intensity-modulated radiotherapy (IMRT)with IMRT without entering pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods: For a cohort of 10 patients, bone marrow-sparing IMRT and routine IMRT planning were designed. Theproscribed dose was 45 Gy/1.8 Gy/25f, 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system (TPS) using convolution/superimposition (CS) algorithm. Plans were compared according to dose-volume histogram (DVH) analysis in terms of planning target volume (PTV) homogeneity and conformity indices (HI and CI) as well as organs at risk (OARs) dose and volume parameters. Results: Bone marrow-sparing IMRT had an vantages over routine IMRT in terms of CI, but inferior to the latter for HI. Compared with routine IMRT, V5,V10, V20, V30, V40 of pelvic bone marrow of bone marrow-sparing IMRT reduced by 1.81%, 8.61%, 31.81%, 29.50%, 28.29%,respectively. No statistically significant differences were observed between bone marrow-sparing IMRT and routine IMRT in terms of small bowel, bladder and rectum. Conclusion: For patients with cervical cancer after hysterectomy, bone marrowsparing IMRT reduced the pelvic bone marrow volume irradiated at all dose levels and might be conducive to preventing the occurrence of acute bone marrow toxicity.关键词
bone marrow sparing/cervical cancer/dosimetry/hysterectomy/postoperative/intensity-modulated radiotherapyKey words
bone marrow sparing/cervical cancer/dosimetry/hysterectomy/postoperative/intensity-modulated radiotherapy引用本文复制引用
Fuli Zhang,Mingmin Zheng,Junmao Gao,Weidong Xu..宫颈癌术后骨髓保护调强放疗研究[J].中德临床肿瘤学杂志（英文版）,2011,10(6):349-353,5.
