南方医科大学学报2011，Vol.31Issue(5)：844-848,5.
光动力疗法治疗豚鼠寻常型银屑病
Therapeutic effect of photodynamic treatment for psoriasis vulgaris in guinea pigs
摘要
Abstract
Objective To observe the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating psoriasis vulgaris in guinea pigs. Methods Experimental psoriasis vulgaris was induced in guinea pigs by application of 5% propranolol on the ear skin. After dressing of the skin lesion with 20% ALA solution for 4 h, the lesions were irradiated with a semiconductor laser at the wavelength of 635 nm and energy density of 12 J/cm2. The guinea pigs were divided into control group, ALA only group, light only group, single ALA-PDT treatment group and twice ALA-PDT treatment group. In each group, gross observation and biopsy of the skin lesions was conducted on days 7, 14, 21 and 28 after the treatment. Results In terms of gross observation of the lesion, epidermal thickness and proliferating cell nuclear antigen (PCNA) expression, ALA-PDT treatment showed obvious therapeutic effect on the skin lesion, and two treatment sessions resulted in better effect than a single session. Conclusion ALA-PDT can cure psoriasis vulgaris lesions characterized by abnormal epidermal proliferation in guinea pigs, and multiple treatment sessions can achieve better effects.关键词
光动力疗法/寻常型银屑病/动物模型Key words
5-aminolevulinic acid photodynamic therapy/psoriasis vulgaris/animal models分类
医药卫生引用本文复制引用
谢光辉,李康英,刘宏伟,段世军..光动力疗法治疗豚鼠寻常型银屑病[J].南方医科大学学报,2011,31(5):844-848,5.基金项目
广东省医学科研基金(A2008361) （A2008361）
