南方医科大学学报2011，Vol.31Issue(5)：882-885,889,5.
肾移植术后侵袭性肺部真菌感染的预后因素分析——单中心10年经验回顾性分析
Factors affecting the prognosis of invasive pulmonary fungal infections after kidney transplantation: analysis of the ten-year single-center data
摘要
Abstract
Objective To investigate the factors affecting the prognosis of invasive pulmonary fungal infection (IPFI) in patients after kidney transplantation. Methods This retrospective study involved 80 concurrent patients with IPFI after receiving kidney transplantation in Zhujiang Hospital from January 1, 2000 to April 1, 2010. Fourteen factors including age, gender, pathogens, body temperature on day 5, renal insufficiency, mechanical ventilation, and clinical pulmonary infection score (CPIS) on day 5 were analyzed by univariate analysis and multivariate Logistic regression analysis to identify the factors related to the prognosis. Results Univariate analysis showed that a normal body temperature on day 5 of antifungal treatment (P=0.024), fasting high blood glucose (P=0.001), renal insufficiency (P= 0.002), malnutrition (P=0.018), time of infection after transplantation (P=0.046), low CPIS on day 5 (P=0.000) and mechanical ventilation (P=0.000) all affected the prognosis of the patients. Logistic regression analysis showed that renal insufficiency (OR=18.096), mechanical ventilation (OR=130.7) and low CPIS on day 5 (OR=0.011) were independent prognostic factors, among which the low CPIS on day 5 was a protective factor. Conclusion Timely and adequate empirical therapy and renal replacement therapy, along with adjusted anti-fungal therapy protocol according to the CPIS score on day 5, may improve the prognosis of IPFI after kidney transplantation.关键词
侵袭性肺部真菌感染/预后因素/肾移植/Logistic分析Key words
invasive pulmonary fungal infections/prognosis factors/kidney transplantation/multivariate logistic regression analysis分类
医药卫生引用本文复制引用
刘丁,蔡绍曦,刘永光,郭颖..肾移植术后侵袭性肺部真菌感染的预后因素分析——单中心10年经验回顾性分析[J].南方医科大学学报,2011,31(5):882-885,889,5.基金项目
广东省重大科技计划项目(2008A060202013) （2008A060202013）
