南方医科大学学报2011，Vol.31Issue(5)：886-889,4.
特发性卵巢早衰的临床特点分析
Clinical features of women with idiopathic premature ovarian failure
摘要
Abstract
Objective To summarize the clinical features of idiopathic premature ovarian failure (POF) and explore the early diagnosis and intervention. Methods A retrospective study was conducted in 39 women with idiopathic POF treated between February, 2009 and January, 2010. The clinical data of the patients including the menstrual feature, POF incidence, vaginal ultrasound and pregnancy outcomes were investigated. Results One patient had primary amenorrhea and 38 had secondary amenorrhea with an average duration of amenorrhea of 5.82 years. Abrupt cessation occurred after 1-2 menstruations following the menarche in 2 cases (5.1% ) and without identifiable preceding signs in 9 cases (23%). The mean uterine and ovarian volume was significantly smaller in POF group than in the control group. Antral follicle count (AFC) was also significantly lower in POF group. Vaginal ultrasound detected at least one ovary in 89.7% and follicular activity in 79.5% of the POF patients. Evidence of ovulation Was found in 12 patients, and spontaneous pregnancy occurred in 2 patients with a pregnancy rate of 5.1%. Conclusion Patients with menstrual disturbance, polymenorrhea and oligomenonrrhea are at risk of developing POF, in which case regular detection of the mean uterine volume, ovarian volume and AFC by vaginal ultrasound may help in early POF detection. Close monitoring can be necessary in the course of hormone replacement therapy, and timely intervention with assisted reproductive techniques may increase the chance of pregnancy.关键词
卵巢早衰/特发性/激素替代Key words
premature ovarian failure/idiopathic/hormone replacement therapy分类
医药卫生引用本文复制引用
覃春容,陈士岭,陈薪,夏容,罗燕群..特发性卵巢早衰的临床特点分析[J].南方医科大学学报,2011,31(5):886-889,4.基金项目
深圳市科技计划项目(201002090) （201002090）
