临床与实验病理学杂志2011，Vol.27Issue(6)：586-589,4.
胃癌组织中p21、p27、p53和Rb的表达及临床意义
Expression of p21, p27, p53 and Rb proteins and their clinical significance in gastric carcinoma
摘要
Abstract
Purpose To investigate the significance of p21 , p27 , p53 and Rb protein expression in the pathogenesis of gastric carcinoma. Methods The expression of p21, p27, p53 and Rb proteins was detected in 111 cases of gastric cancer, 38 cases of dysplasia,47 cases of intestinal metaplasia, 25 cases of chronic atrophic gastritis and 53 cases of normal gastric mucosa by EnVision immunohistochemistry. Results The highest expression level of p21 and p27 protein was observed in the atypical hyperplasia, followed by gastric cancer, and there were significant difference( P ＜ 0. 001 )compared with the normal gastric mucosa. The expression of p21 , p27 , p53 and Rb proteins in gastric cancer was significantly higher than that in normal gastric mucosa ( all P ＜ 0. 01 ). p21 and p27 protein expression was related to gastric cancer type and differentiation ( P ＜ 0. 01 ). p53 expression level was related to patient' s age, sex,tumor type and patient ' s survival rate. Rb protein expression in female patients was significantly higher than that in male patients ( P ＜0. 05 ). Significant correlations were found in the expression of p21, p27 , p53 and Rb proteins. Conclusions The expression of p21 , p27 , p53 and Rb proteins might be a helpful marker for the diagnosis of gastric carcinoma, and these four proteins might play a synergistic role in the evaluation of the biology behavior of gastric carcinoma.关键词
胃肿瘤/p21/p27/p53/RbKey words
stomach neoplasms/ p21 / p27 / p53 / Rb分类
医药卫生引用本文复制引用
张凤艳,张金子,邹树彪,程志芬,才勇,玄延花..胃癌组织中p21、p27、p53和Rb的表达及临床意义[J].临床与实验病理学杂志,2011,27(6):586-589,4.基金项目
国家自然科学基金(30960403) （30960403）
国家教育部留学回国人员科研启动基金(教外司留20071108) （教外司留20071108）
