临床与实验病理学杂志2011，Vol.27Issue(6)：590-593,4.
胃腺癌中PAR-2、β-catenin和COX-2的表达及其意义
Expression of PAR-2, β-catenin and COX-2 in gastric adenocarcinoma
俞敏 1冯一中 2高璀乡1
作者信息
- 1. 苏州大学医学部病理学与病理生理系,苏州,215123
- 2. 江苏省盐城卫生职业技术学院,盐城,224005
- 折叠
摘要
Abstract
Purpose To study the expression of protease-activated receptor-2 ( PAR-2 ), β-catenin and COX-2 in gastric adenocarcinoma and their correlation with clinicopathological features and survival time. Methods hnmunohistochemical SP method was used to determine the expression of PAR-2, β-catenin and COX-2 in 63 cases of gastric adenocarcinoma and 20 cases of normal gastric mucosal tissues. Results The positive expression of PAR-2 and COX-2 in gastric adenocarcinoma was much higher than that in low-grade intraepithelial neoplasia and in normal gastric mucosal tissues, the abnormal expression of β-catenin in gastric adenocarcinoma was much higher than that in low-grade intraepithelial neoplasia and in normal gastric mucosal tissues. The positive expression of PAR-2 in carcinoma tissue was closely correlated with depth of invasion ( P ＜ 0. 05 ), the abnormal expression of β-catenin in carcinoma tissue was closely correlated with differentiation degree, depth of invasion, lymph node metastasis and TNM stages ( P ＜ 0. 05 );the positive expression of COX-2 in carcinoma tissue was closely correlated with the depth of invasion, lymph node metastasis and TNM stages( P ＜0. 05 ). According to the method of Kaplan-Meier, the difference between the positive expression group of PAR-2, COX-2 and the negative group was of statistical significance in gastric adenocarcinoma, and that between the abnormal expression group of β-catenin and the normal group was also of statistical significance in gastric adenocarcinoma. Conclusions The positive expression of PAR-2 is correlated with the progression of gastic carcinoma, and it may have some reference to evaluate the prognosis. The abnormal expression of β-catenin and the positive expression of COX-2 are closely correlated with the carcinogenesis and progression of gastic carcinoma, and they may be valuable prognosic markers.关键词
胃肿瘤/腺癌/PAR-2/β-catenin/COX-2/免疫组织化学Key words
stomach neoplasms/ adenocarcinoma/ PAR-2/ β-catenin/ COX-2/ immunohistochemistry分类
医药卫生引用本文复制引用
俞敏,冯一中,高璀乡..胃腺癌中PAR-2、β-catenin和COX-2的表达及其意义[J].临床与实验病理学杂志,2011,27(6):590-593,4.
