临床与实验病理学杂志2011，Vol.27Issue(6)：603-606,4.
CD99在胰腺内分泌肿瘤中的表达及预测价值
Expression of CD99 and its predictive value in pancreatic endocrine tumors
王良瑛 1马伟元 1王妍 2刘文君 2杨敏 2张廷国1
作者信息
- 1. 山东大学医学院病理教研室,济南,250012
- 2. 山东大学齐鲁医院病理科,济南,250012
- 折叠
摘要
Abstract
Purpose To examine the expression of CD99 in pancreatic endocrine tumors ( PETs ) and to analyze the correlation with clinicopathologic parameters. Methods Analyses of 34 PETs was undertaken to perform immunohistochemical staining with CD99 and to evaluate the correlation with clinicopathologic features. Results Of the 34 PETs, 18 cases ( 53％ ) were CD99-positive, 5 cases with local invasion ( including the 2 lymph node involvement ) were all CD99-negative; 1 with spleen and liver metastases showed less than 30％ of the tumor population being CD99-positive. The expression of CD99 was significantly correlated with gross local invasion,metastasis to the lymph nodes or other organs, and histological grade. However, tumor size and functional status showed no significant association with CD99 expression. The follow-up results showed that loss/low expression of CD99 may be correlated with a poor prognosis of the PETs. Conclusion This study confirms that the expression of CD99 is significantly correlated with the hehavior of PETs.CD99 loss/low expression is associated with malignant progression and a poor prognosis of the PETs. It may prove to be an independent prognostic predictor of PETs.关键词
胰腺肿瘤/内分泌肿瘤/CD99/预后Key words
pancreatic neoplasms / endocrine tumors/ CD99/ prognosis分类
医药卫生引用本文复制引用
王良瑛,马伟元,王妍,刘文君,杨敏,张廷国..CD99在胰腺内分泌肿瘤中的表达及预测价值[J].临床与实验病理学杂志,2011,27(6):603-606,4.
