实用肿瘤杂志2011，Vol.26Issue(3)：266-268,3.
胃肠道恶性肿瘤患者含奥沙利铂辅助化疗慢性神经毒性的相关因素分析
Analysis of correlative factors of neurotoxicity of gastric cancer and intestinal cancer patients after radical resection with oxaliplatin chemotherapy
沈秋萍 1范明珠 1来雷 1沈礼平 1徐力1
作者信息
- 1. 桐乡市第一人民医院肿瘤内科,浙江,桐乡,314500
- 折叠
摘要
Abstract
Objective To study the correlative factors of neurotoxicity associated with oxaliplatin (L-OHP).Methods Sixtyfour cases of gastric cancer and intestinal cancer after radical resection who used L-OHP and 5-FU/CF chemotherapy were collected in the study.At the end of the sixth cycle,the grade of neurotoxicity, gross of L-OHP, interval time of L-OHP, patient age,sex, stage and position of tumor and toxic reaction were recorded.Results All the factors were analyzed with Logistic regression model( α = 0.05 ),six factors were identified in the univariate analysis, including patient age, gross of L-OHP, interval time of L-OHP, arrest of bone marrow, gastrointestinal reaction and hepatic dysfunction.The results of Logistic multivariate analysis( α = 0.05 ) indicated that patient age, gross of L-OHP, interval time of L-OHP and arrest of bone marrow were the correlative factors.Conclusion The dosage of L-OHP shottld be regulated to alleviate oxaliplatin-related neurotoxicity based on the patient age and other factors.关键词
胃肠肿瘤/药物疗法,联合/奥沙利铂/治疗应用/因素分析/统计学/生活质量分类
医药卫生引用本文复制引用
沈秋萍,范明珠,来雷,沈礼平,徐力..胃肠道恶性肿瘤患者含奥沙利铂辅助化疗慢性神经毒性的相关因素分析[J].实用肿瘤杂志,2011,26(3):266-268,3.
