中国医学科学院学报2011，Vol.33Issue(2)：107-110,后插1,5.DOI:10.3881/j.issn.1000-503X.2011.02.001
18F-脱氧葡萄糖正电子发射计算机断层显像在库欣病诊断和术前定位中的价值
Value of [18F] fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography in Diagnosis and Localization of Cushing's Disease
程欣 1崔瑞雪 1潘慧 2袁涛 2朱惠娟 2李方1
作者信息
- 1. 中国医学科学院,北京协和医学院,北京协和医院,核医学科,北京,100730
- 2. 中国医学科学院,北京协和医学院,北京协和医院,内分泌科,北京,100730
- 折叠
摘要
Abstract
Objective To explore the value of [ 18F ] fluoro-2-deoxy-D-glucose ( 18 FDG) positron emission tomography and computer tomography (PET/CT) in the qualitative diagnosis and localization of Cushing's disease. Methods Totally 12 patients underwent transsphenoidal adenomeetomy and were histopathologieally proven to be with Cushing's disease. 18FDG PET/CT whole-body and brain scannings were performed preoperatively; meanwhile, magnetic resonance imaging (MRI) and 99mTc-octreotide examination were done in all 12 cases, and inferior petrosal sinus sampling (IPSS) were done in 6 patients. Results The sensitivity of 18FDG in diagnosing Cushing's disease was 91.6％ (11/12) , but URI was 66.7％ (8/12). For the 6 patients who performed IPSS, 5 of them was diagnosed to be with Cushing's disease, and only 50％ (3/6)were localized correctly in the pituitary gland. Conclusions 18FDG PET/CT whole-body scan can exclude ectopic adrenocorticotropin-secreting tumors, and localize the pituitary lesions with higher accuracy than MRI.Therefore, it is useful for suspected Cushing's disease, especially for patients their MRI and IPSS have negative or paradoxical results.关键词
库欣病/正电子发射计算机断层显像/垂体腺瘤/《'18》F-脱氧葡萄糖Key words
Cushing's disease/ positron emission tomography/ pituitary adenomas/ [ 18F ] fluoro-2-deoxy-D-glucose分类
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程欣,崔瑞雪,潘慧,袁涛,朱惠娟,李方..18F-脱氧葡萄糖正电子发射计算机断层显像在库欣病诊断和术前定位中的价值[J].中国医学科学院学报,2011,33(2):107-110,后插1,5.
