中国医学科学院学报2011，Vol.33Issue(2)：162-168,7.DOI:10.3881/j.issn.1000-503X.2011.02.013
高龄高血压患者外周动脉性疾病患病率及危险因素
Prevalence and Risk Factors of Peripheral Arterial Diseases in Male Chinese Octogenarians and Nonagenarians with Hypertension
摘要
Abstract
Objective To investigate the prevalence and risk factors of peripheral arterial disease (PAD) in male Chinese octogenarians and nonagenarians with hypertension. Methods Ankle-brachial index (ABI) was measured in the noninvasive vascular laboratory for hypertensive male octogenarians and nonagenari ans enrolled from outpatient and inpatient departments. The baseline conditions were investigated using standard questionnaire and by routine physical examinations. PAD was diagnosed when an ABI ≤0.9 in either lower extremity. Results Totally 290 male Chinese octogenarians and nonagenarians [ age: (84.61 ± 4.20 ) years ]with hypertension who were receiving antihypertensive therapy were enrolled in this study, among whom 9 men with missing data except age and ABI measurements. The ABI was 0. 948 ± 0. 258, with the range of highest frequency of 0.91-1.30, and 106 patients were diagnozed as PAD, 182 as non-PAD, and 2 had ABI ＞ 1.3.ABI in hypertensive men with PAD were significantly lower than in those without PAD ( P ＜ 0.05 ). On the contrary, age, blood urea nitrogen, white blood cell counts, platelets and aspartic transaminase were significantly higher in PAD patients than in non-PAD patients ( all P ＜ 0.05 ). The prevalence of PAD in this study population were 36.5％; more specifically, it significantly differed between different subgroups when stratified by age (28.6％ vs. 46.3％, below and above 85 years), with and without hypertension (27.5％ vs.40. 1％ ), stroke ( 44.7％ vs. 27.5％ ), dyslipidemia ( 41.4％ vs. 33.3％ ), coronary artery disease (44.1％ vs. 13.9％ ) , and diabetes mellitus (53.7 ％ vs. 21.8 ％ ) ( all P ＜ 0.05 ). The prevalences of PAD in hypertensive patients treated with diuretics, calcium antagonists, beta-blocker, or angiotensin receptor antagonist were 41.4％ , 36. 1％ , 22.4％, and 26.8 ％, respectively. No association was observed between the prevalence of PAD and smoking/alcohol drinking in these subjects. Multivariate analysis showed that age ( OR 1.12, 95％ CI 1. 014-1. 238) , blood urea nitrogen ( OR 1.15,95％ CI 1. 025-1. 301 ) , aspartic transaminase ( OR 1.05, 95％ CI 1. 005-1. 089) , diabetes mellitus ( OR 4.02, 95％ CI 1. 797-9.009) , coronary artery disease (OR 6.34, 95％ CI 1. 734-23. 214) were strong risk factors of PAD. Conclusion PAD is highly prevalent among aged Chinese hypertensive men, in which age, blood urea nitrogen, aspartic transaminase, diabetes mellitus, coronary artery disease may be involved in the development of this condition.关键词
高血压/外周动脉疾病/踝肱指数/危险因素Key words
hypertension/ peripheral arterial disease/ ankle brachial index/ risk factors分类
医药卫生引用本文复制引用
丁一妹,王玉,李燕,杨培,刘敏艳,刘亮,朱平,李小鹰..高龄高血压患者外周动脉性疾病患病率及危险因素[J].中国医学科学院学报,2011,33(2):162-168,7.基金项目
国家十一五新药研发技术平台资助课题(2008ZX09312-006-02) （2008ZX09312-006-02）
