中国医学科学院学报2011，Vol.33Issue(2)：169-174,后插5,7.DOI:10.3881/j.issn.1000-503X.2011.02.014
基于磁共振分级的膝关节骨关节炎关节软骨T2图
T2 Mapping of Articular Cartilage in Knee Osteoarthritis Using A Magnetic Resonance Staging
胡娜 1刘东 2金征宇 2张燕 2盛敏 2吴志宏 2金今 3包飞 3孟薇 4徐进 2姜波2
作者信息
- 1. 四川大学,华西医院放射科,成都,610041
- 2. 中国医学科学院,北京协和医学院,北京协和医院,放射科,北京,100730
- 3. 中国医学科学院,北京协和医学院,北京协和医院,骨科,北京,100730
- 4. 中国医学科学院,北京协和医学院,北京协和医院,针灸科,北京,100730
- 折叠
摘要
Abstract
Objective To evaluate T2 mapping of articular cartilage in knee osteoarthritis (OA). Methods Totally 38 healthy subjects ( group H) and 53 OA patients received scoring with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and underwent T2 mapping of tibiofemoral articular cartilages. The T2 values in 10 subregions of the cartilages were measured. Patients in the OA group were further divided into OA1 group and OA2 group using the modified Magnetic Resonance Recht Grading System. In OA group, the fat-suppressed three-dimensional fast spoiled gradient echo MRI was performed to obtain the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). The differences of T2 values among group H, group OA1, and group OA2 were compared. The correlation between T2 value and WORMS/WOMAC scores was analyzed. The intra- and inter-observer reproducibility of measurement was calculated. Results The T2 values in all the subregions ranged 43.9-53.6ms in group H, 41.1-55.0 ms in group OA1, and 45.6-56. 1 ms in group OA2. T2 values in group OA2 were significantly higher in central medial femoral subregion, central medial, and lateral tibial subregions compared with group H, also significantly higher in central medial femoral subregion, anterior and central medial tibial subregions compared with group OA1 ( P ＜ 0.05 ). T2 values were significantly correlated with WORMS scores (R= 0. 307-0. 811, P ＜ 0.01 ) except in posterior lateral femoral subregion, but not with WOMAC scores. The correlation coefficients for intra- and inter-observer measurement showed good reproducibility (R ＞ 0. 740, P ＜ 0. 05 ) except in anterior lateral tibial subregion for inter-observer of measurement. Conclusion T2 mapping can differentiate the OA severity of knee cartilage using a magnetic resonance staging, and therefore can be a sensitive technique for monitoring the severity of OA.关键词
膝关节/骨关节炎/关节软骨/磁共振成像/T2图Key words
knee joint/ osteoarthritis/ articular cartilage/ magnetic resonance imaging/ T2 mapping分类
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胡娜,刘东,金征宇,张燕,盛敏,吴志宏,金今,包飞,孟薇,徐进,姜波..基于磁共振分级的膝关节骨关节炎关节软骨T2图[J].中国医学科学院学报,2011,33(2):169-174,后插5,7.
