南方医科大学学报2011，Vol.31Issue(4)：578-581,4.
氟伐他汀拮抗溶血磷脂酰胆碱致心律失常作用的机制研究
Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced ventricular arrhythmias in rats
摘要
Abstract
Objective To investigate the effect of fluvastatin on lysophosphatidylcholine (LPQ-induced ventricular arrhythmias and its mechanism. Methods Twenty male SD rats were randomly allocated into two equal groups, namely LPC treatment group and fluvastatin pretreatment group. Langendorff apparatus was used for cardiac perfusion ex vivo with 5 μnol/L LPC for 5 min followed by washing for 30 min in LPC treatment group, and in fluvastatin pretreatment group, a 30-min perfusion with 10 μmol/L fluvastatin was administered before LPC perfusion. The LPC-induced nonselective cation current (W) in the ventricular myocytes was recorded using the whole-cell voltage-damp method. Results Fluvastatin significantly inhibited LPC-induced ventricular tachyarrhythmia/fibrillation and IMSC- The small G-protein Rho inhibitor (C3) and Rho-kinase inhibitor (Y-27632) in the pipette solution also suppressed LPC-induced W. Conclusions Fluvastatin offers cardiac protection against LPC by inhibiting LPC-induced Insc. LPC induces fatal arrhythmia via a Rho/Rho-kinase-mediated pathway.关键词
溶血磷脂酰胆碱/心律失常/氟伐他汀/离子通道/Rho/Rho激酶信号途径Key words
Lysophosphatidylcholine/ arrhythmia/ fluvastatin/ ion channel/ Rho/Rho-kinase-mediated pathway分类
医药卫生引用本文复制引用
李力兵,王洪叶,马兰,高长青..氟伐他汀拮抗溶血磷脂酰胆碱致心律失常作用的机制研究[J].南方医科大学学报,2011,31(4):578-581,4.基金项目
国家自然科学基金(30670823 （）
30971182) （）
