南方医科大学学报2011，Vol.31Issue(4)：615-618,4.
抗MICA抗体的致敏因素分析及其对肾移植的影响
Anti-MICA antibodies: risk factors for sensitization and the impact on renal transplantation outcomes
摘要
Abstract
Objective To investigate the risk factors for sensitization of anti-MICA antibodies and their impact on the outcomes of renal transplantation. Methods Luminex flow cytometry were used to identify 10 MICA antibodies and evaluate the antibody specificity in 98 uremic patients positive or negative for anti-MICA antibodies undergoing kidney transplantation. The factors contributing to MICA sensitization were analyzed, and the incidence of acute rejection and graft function recovery time were compared between the positive and negative cases for anti-MICA antibodies. Results Of the 98 uremic patients, 16 (16.3%) were positive for anti-MICA antibodies. The positive and negative cases showed significant differences in the history of blood transfusion, pregnancy, transplantation, and PRA status (P＜0.05). In the 38 renal transplant recipients, 6 experienced acute graft rejection, which was reversed by methylprednisolone pulse therapy; of the 10 recipients positive for anti-MICA antibodies, 4 showed acute graft rejection as compared to 2 out of the 28 recipients negative for anti-MICA antibodies (P=0.031). The cases positive for anti-MICA antibodies showed a significantly longer graft function recovery time than the negative cases (14.6±4.7 vs 8.2 ±4.5 days, P=0.001). Conclusion Blood transfusion, pregnancy, and transplantation all contribute to the production of anti-MICA antibodies. Patients positive for anti-MICA antibodies may require strict HLA matching and more potent immunosuppressive drugs to prevent renal graft rejection and improve graft survival.关键词
抗MICA抗体/终末期肾脏疾病/肾移植Key words
anti-MICA antibodies/ end-stage renal diseases/ renal transplantation分类
医药卫生引用本文复制引用
于立新,王贵,付绍杰,肖露露,徐健,杜传福..抗MICA抗体的致敏因素分析及其对肾移植的影响[J].南方医科大学学报,2011,31(4):615-618,4.基金项目
国家自然科学基金(81070594) （81070594）
广东省科技计划项目(2010B031600240) （2010B031600240）
广东省自然科学基金(815105150-1000047) （815105150-1000047）
