摘要
Abstract
Objective: To observe the clinical effects of combined use of transmetil ( SAMe ) and ursodcoxycholic acid ( UDCA ) in the treatment for viral hepatitis B with high aundice. Method: 69 cases of viral hepatitis B with high aundice were randomly divided into three groups: SAMe group with intravenous SAMe 1000rag/times, 1 time/d; UDCA group with oral SAMe, 50rug with once,3 times per day; combined group with both treatments above. The change value of ALT, AST, TBil, DBil, TBA and improvement of clinical manifestation before and 1 week,2 weeks after treatment were recorded. All data was statistically analyzed by X2 test and t test. Result: There was only ALT decrease dramatically and no statistical difference when comparing the three groups 1 week after treatment ( P＞0.05 ). However, after 2 weeks, there were great reductions in the levels of ALT, AST, TBil, DBil, TBA and 66.7％ of patients with jaundice and 32.3％ of patients with hepatomegalia were improved. There＇s no statistical difference between SAMe group and UDCA group(P＞O.05 ), but combined group was superior to the efficacy of than each of single therapy ( P＜O.05 ). Conclusion: Combined use of SAMe and UDCA in the treatment for viral hepatitis B with high aundice is superior to the efficacy of than each of single therapy, but there was no statistical difference between SAMe and UDCA. These results provide the reference to the clinical practice and guidance to election of treatment methods.关键词
肝炎/思美泰/优思弗Key words
Hepatitis/ Transmetil/ Ursodeoxyeholie acid
