中国实用妇科与产科杂志2011，Vol.27Issue(5)：374-376,3.
上皮样滋养细胞肿瘤临床病理特点及预后分析
Clinicopathologic features and prognosis factor analysis in patients with epithelioid trophoblastic tumor
摘要
Abstract
Objective To investigate the clinicopathologic features and prognosis factor in patients with epithelioid trophoblastie tumor (ETT).Methods Nine patients with ETT were treated at Peking Union Medical College Hospital (PUMCH) between Jan 2002 and Ang 2010.The elinicopathologie characteristics, treatments, outcomes and prognosis were studied retrospectively in our institution.Results Seven of nine cases had metastases (7/9, 77.8％ ), four of them with multiple organ metastases.The histopathology results of seven patients with poor outcome showed diffuse multifocal disease within the uterus, full-thickness myometrial invasion, uterine serosal involvement and extensive necrosis.The uterine size was greater than the equivalent of 8 weeks'gestation in six of them.Two of them had poorly differentiated carcinoma.All patients were treated with multimodality treatment which combined with surgery and chemotherapy.After initial treatments, five patients achieved a complete remission (CR), one reached an initial partial remission (PR), and three patients (3/9, 33.3％ ) had no response to treatments and died of progressive disease.After followed up for 2 ～103 months ( mean, 24.5 months), three cases (3/9, 33.3％ ) of five patients with initial CR presented signs of recurrence reached CR by aggressive multimodality treatment.Conclusion The degree of malignancy of ETT is higher than placental site trophoblastic tumor.To improve survival in ETT we should increase early diagnostic accuracy, identify prognostic factor in an early stage and provide promptly exactitude multimodality treatment to the patients with poor prognostic factors.关键词
中间型滋养细胞肿瘤/上皮样滋养细胞肿瘤/预后分类
医药卫生引用本文复制引用
沈晓燕,向阳,郭丽娜,冯凤芝,万希润..上皮样滋养细胞肿瘤临床病理特点及预后分析[J].中国实用妇科与产科杂志,2011,27(5):374-376,3.基金项目
十一五国家科技支撑计划课题(2008BAI57B05) （2008BAI57B05）
