中国中医药信息杂志2011，Vol.18Issue(4)：34-35,2.DOI:10.3969/j.issn.1005-5304.2011.04.014
丹参软肝饮对肝纤维化大鼠肝功能及肾素-血管紧张素-醛固酮系统的影响
Influence of Danshen Ruangan Yin on Liver Fibrosis and RAAS of Rats
摘要
Abstract
Objective To observe the therapeutic effect of Danshen Ruangan Yin on hepatic fibrosis rats induced by CCl4 and its influence on renin-angiotensin-aldosterone system (RAAS), and to explore the antihepatofibrotic mechanism of Danshen Ruangan Yin. Methods Except 10 rats of normal control, other rats were induced by hypodermic injecting 40％ CCl4-olive oil mixture for 6 weeks to duplicate liver fibrosis,and then administrated with drugs based on groups (model, Enalapril, Danshen Ruangan Yin high,middle and low dosage) for 5 weeks. Serum ALB, ALT, AST, SOD, MDA, ACE, PRA, AngⅡ and ALD were detected. Results Danshen Ruangan Yin could decrease activity of ALT and AST, increase content of ALB,raise activity of SOD and depress content of MDA. Compared with model group, Danshen Ruangan Yin could decrease ACE, ALD and Ang Ⅱ significantly as well as increase PRA. Conclusion Danshen Ruangan Yin can improve liver function of hepatic fibrosis rats induced by CCl4 and inhibit plasma RAAS.关键词
丹参软肝饮/肝纤维化/肾素-血管紧张素-醛固酮系统/大鼠分类
医药卫生引用本文复制引用
姚立,余静,李珏..丹参软肝饮对肝纤维化大鼠肝功能及肾素-血管紧张素-醛固酮系统的影响[J].中国中医药信息杂志,2011,18(4):34-35,2.基金项目
浙江省自然科学基金(Y205335) （Y205335）
