重庆医学2011，Vol.40Issue(17)：1725-1727,封3,4.DOI:10.3969/j.issn.1671-8348.2011.17.025
中期因子与血管内皮生长因子C在胰腺肿瘤组织中的表达及其意义
Expression and significance of Midkine and VEGF-C in pancreatic carcinoma
周红兵 1张秀忠 2任泽强2
作者信息
- 1. 泰州市人民医院普外科,江苏泰州,225300
- 2. 徐州医学院附属医院普外科,江苏徐州,221001
- 折叠
摘要
Abstract
Objective To explore expression and significance of Midkine(MK) and vascular endothelial growth factor-C(VEGFC) in pancreatic carcinoma.Methods Streptavidin-perosidase(SP) immunohistochemistry was employed to detect expression of MK and VEGF-C in tissues of pancreatic carcinoma, carcinoma adjacent tissues and chronic pancreatitis.A contingency table was created to conduct x2 test and the Spearman Rank Correlation was used to investigate the relationship between the expression of MK and VEGF-C and clinicopathologic factors such as age and gender of patients.size and location of tumor,lymph nodes metastasis and clinical TNM stages.Results The positive expressions of MK and VEGF-C in terms of the number and percentage of their specimens in pancreatic carcinoma tissues were notably higher than their expressions in carcinoma adjacent tissues and chronic pancreatitis tissues(P＜0.05).The differences in the expression of MK and VEGF-C in pancreatic tissues of patients with different clinical TNM stages, regional or non-regional lymph node metastasis were found to be statistically significant(P＜0.05).The expression of VEGF-C in panceatic carcinoma tissues was observed to have positive correlation with that of MK(r=0.68,P＜0.05).Conclusion MK and VEGF-C may be used as indicators for early diagnosis of pancreatic carcinoma, estimating tumor progressionand metastasis.关键词
胰腺肿瘤/中期因子/血管内皮生长因子C/淋巴转移Key words
pancreatic neoplasms / midkine / vascular endothelial growth factor-C/ lymphatic metastasis引用本文复制引用
周红兵,张秀忠,任泽强..中期因子与血管内皮生长因子C在胰腺肿瘤组织中的表达及其意义[J].重庆医学,2011,40(17):1725-1727,封3,4.
