山东医药2011，Vol.51Issue(22)：4-6,3.
丹参对肾移植大鼠慢性排斥移植肾病理变化及其TGF-β1表达的影响
Effect of salviae miltiorrhizae on histological changes and TGF-β1 expression in chronic renal allograft rejection rat kidney post-transplanted
摘要
Abstract
Objective To explore the effect of salviae miltiorrhizae powder injection on histological changes and TGFβ1 expression in choronic renel allograft rejoection rat kindney pest-transplanted chronic renal allograft rejection. Methods Orthotopic kidney transplantation were performed in strain combinations of SD to Wistar. The native kidney of the recipients were kept and used as an internal control. 15 successfiul recipients were randommized into treating group( n =8)and control group(n =7). The recipients of the two groups were treated with salviae miltiorrhizae powder for injection at doses of 80 mg/( kg · d) ( treating group)or the same volume of saline solution( control group) per day from day 10 until week 12 after transplantation. All receipients of each group were killed on week 12 after transplantation, the histology examination of grafts and the native kidneys was performed in parallel according to the Banff working classification for renal allograft pathology. Immunohistochemistry of TGF-β1 of each allograft was examined and was semiquantitatively evaluated. Results All allografts of each group survived up to 12 weeks after transplantation and develop chronic renal allograft rejection, characterized by neointimal hyperplasia, interstitial fibrosis, tubular atrophy, g lomerulosclerosis and mononuclear cell infiltration.Compared with those in the control group, the Banff sum scores and TGF-β1 expressions in the renal allograft tissues were significantly decreased in the treatming group on week 12 ( P ＜ 0. 01 ). The native kidney of recipients of each group showed no inflammation or histological alterations. Conclusions Salviae miltiorrhizae can reduce the histological damages and the expresion of TGF-β1 in the renal allograft tissues effectively.关键词
丹参/病理学/肾移植术/慢性排斥反应/转化生长因子β1/大鼠Key words
salviae miltiorrhizac/ pathology/ kidney transplantation/ chronic allograft rejection/ transforming growth factor β1/ rat分类
医药卫生引用本文复制引用
余鹏程,胡义阳,岳良升,陈桦,郭颖,李民,吴建平,赵明..丹参对肾移植大鼠慢性排斥移植肾病理变化及其TGF-β1表达的影响[J].山东医药,2011,51(22):4-6,3.基金项目
广东省泉州市科技计划基金资助项目(2009Z39). （2009Z39）
