中医药学报2011，Vol.39Issue(2)：51-55,5.
大黄黄连泻心汤、理中丸对四种模型胃溃疡寒热证大鼠血清PAF含量的影响
The Effect of Dahuang Huanglian Xiexin Decoction and Lizhong Pills on PAF Contents in Serum on Four Kinds of Gastric Ulcer Models Combined with Cold or Heat Syndrome Rats
摘要
Abstract
Objective :To explore the forming mechanism of gastric ulcer model induced by indomethacin ,water immersion stress, pylorus deligation and smearing acetic acid combined with cold or heat syndrome.And to observe the basic and objective regularity of "formula - syndrome corresponding" of cold or heat formula on gastric ulcer model combined with cold or heat syndrome.Methods: Adopting cold or heat factors combined four methods to establish gastric ulcer model combined with cold and heat syndrome.Using ELISA to detect the influence of Dahuang Huanglian Xiexin Decoction and Lizhong Pill on PAF contents in gastro - tissue.Results: Compared to the blank group, the contents of PAF in stomach - tissue of every modle - group increased remarkably.( P ＜ 0.05 or P ＜ 0.01 ) Dahuang Huanglian Xiexin Decoction can decrease the contents of PAF in stomach - tissue of heat - ulcer group obviously.Lizhong Pill can decrease the contents of PAF in stomach - tissue of cold - ulcer group strikingly.( P ＜ 0.05 or P ＜ 0.0l ) Conclusions: On the basis of the theory of "formula - syndrome corresponding", verifying the success of duplicating "disease - syndrome combination model" , that is gastric ulcer model combined with cold and heat syndrome.The therapeutic action of Dahuang Huanglian Xiexin Decoction on heat - gastric ulcer, or Lizhong Pill on cold - gastric ulcer both can be achieved by decreasing the contents of PAF in stomach - tissue.关键词
大黄黄连泻心汤/理中丸/寒热证/胃溃疡/PAFKey words
Dahuang Huanglian Xiexin decoction/ Lizhong pill/ Cold or heat syndrome/ Gastric ulcer/ PAF分类
医药卫生引用本文复制引用
毕珺辉,李冀,谢田,赵雪莹,于海,蒋蕾,赵伟国,柴剑波..大黄黄连泻心汤、理中丸对四种模型胃溃疡寒热证大鼠血清PAF含量的影响[J].中医药学报,2011,39(2):51-55,5.基金项目
"十一五"国家科技支撑计划项目(编号:2006BAI08B04-03) （编号:2006BAI08B04-03）
黑龙江省中医药管理局项目(编号:ZHY10-W01) （编号:ZHY10-W01）
哈尔滨市青年创新人才基金(编号:2009RFQXS003) （编号:2009RFQXS003）
