工业微生物2011，Vol.41Issue(3)：90-98,9.DOI:10.3969/j.issn.1001-6678.2011.03.018
微生物发酵法生产L-苯丙氨酸的研究进展
Recent advances in L-phenylalanine production by microbial fermentation
摘要
Abstract
L-phenylalanine (L-Phe) is an in portant kind of essential am ino acids . It is widely used in the fields of food ,feed additives and pharm aceutics . L-Phe can be obtained by chemical , enzym atic orm icrob ialprocesses . L-Phe production viamicmbial ferm entation is more promising due to its low cost of raw matenal , less environm ental pollution and high purity of product. In this review , Escherichia coliasamain example , the L-Phe biosynthesis pathway and the regulation of key enzymes , strategies of metabolic regulation for enhanced L-Phe biosynthesis , and the key techniques and strategies applied inferm entative production of L-Phe were analyzed and sum marized respectively . Based on the understanding of the currennt challenges , the prospects of L-Phe production by microbial ferm entation were proposed关键词
L-苯丙氨酸/微生物发酵/大肠杆菌/生物合成/代谢调节Key words
L-phenylalanine / microbial ferm entation / Escherichia coli/ biosynthesis / metabolic regulation引用本文复制引用
周海岩,刘龙,王天文,堵国成,陈坚..微生物发酵法生产L-苯丙氨酸的研究进展[J].工业微生物,2011,41(3):90-98,9.基金项目
973项目(2007CB714306) （2007CB714306）
973前期研究专项(2010CB535014) （2010CB535014）
国家杰出青年基金项目(20625619) （20625619）
国家自然科学基金重点项目(20836003) （20836003）
中央高校基本科研业务费专项(JUSRP30901). （JUSRP30901）
