中国临床药理学杂志2011，Vol.27Issue(4)：265-267,3.
非小细胞肺癌中Notch信号传导通路及VEGF蛋白表达的研究
Study on expression of Notch signal pathway and VEGF in human non - small cell lung cancer
蒋鹏 1岑浩锋 1毛勇 1袁小东 1吴彪1
作者信息
- 1. 宁波市鄞州第二医院胸外科,浙江,宁波315000
- 折叠
摘要
Abstract
Objective To research the expressions of Notch 1, Delta 4 and vascular endothelial growth factor (VEGF) in human non -small cell lung cancer (NSCLC) and to explore its clinical significance. Methods Immunohistochemical SP method was used to detect the expressions of Notch 1, Delta 4 and VEGF in these 55 NSCLC tissues and 30 normal epithelial tissues of the lung. The RT - PCR was used to detect the mRNA of Notch 1, Delta 4 and VEGF. Cases were selected from those patients who were admitted from Jan 2008 to Jan 2010 to our hospital, and diagnosed as NSCLC. Controls were selected from patients admitted to other than malignant lung tumors, who met the same age and residential criteria for eligibility as the cases. Results The positive rates and mRNA level of Notch 1, Delta and VEGF in NSCLC were higher than those in normal epithelial tissues of the lung (P ＜ 0. 05). Expression of Notch 1, Delta4 and VEGF were closely related with the tumor stage, the tumor differentiation and lymph node metastasis (P ＜ 0. 05 ). Conclusion The expression of Notch 1, Delta4 and VEGF play an important role in the progress of lung cancer, and in evaluating the prognosis of NSCLC.关键词
Notch1/Delta4/血管内皮生长因子/非小细胞肺癌Key words
Notch 1 /Delta4/ vascular endothelial growth factor/ nonsmall cell lung cancer分类
医药卫生引用本文复制引用
蒋鹏,岑浩锋,毛勇,袁小东,吴彪..非小细胞肺癌中Notch信号传导通路及VEGF蛋白表达的研究[J].中国临床药理学杂志,2011,27(4):265-267,3.
