中国临床药理学杂志2011，Vol.27Issue(4)：272-275,4.
回顾性分析本院抗菌药使用与G-菌耐药率变化的相关性
Retrospective analysis the relationships between antimicrobial use and antimicrobial resistance in Gram - negative bacteria from a university hospital in Chongqing
陈勇川 1彭永富 1张成 1蔡永青 1熊丽蓉 1谢林利 1夏培元1
作者信息
- 1. 第三军医大学西南医院药学部,重庆4000381
- 折叠
摘要
Abstract
Objective To evaluate the relationship between antimicrobial resistance and antimicrobial use in southwest hospital in Chongqing Methods Disk susceptibility data of Escherichia coli, Klebsiella pneumoniae , Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii. , Stenotrophomonas maltophilia causing nosocomial infections were evaluated. Data on quarter patient and consumption [ defined daily dose (DDD) per 1000 patient] of extended -spectrum cephalosporins (cefotaxime, ceftriaxone, ceftazidime, flumoxef, cefepime et al), β-lactam lactamase inhibitor combinations ( ticarcillin/clavulanic acid, piperacillin/tazobactam, et al), carbapenems ( imipenem, panipenem and meropenem), aminoglycosides( amikacin, gentamicin and tobramycin, et al), fluoroquinolones ( ciprofloxacin, levofloxacin and moxifloxacin, et al) from 2004 to 2009 were analysed. Results The rise in cefepime resistant E. coli and imipenem - resistant Acinetobacter baumannii was significantly correlated with increased consumption of cefepime and imipenem, respectively. Increased imipenem - resistant Acinetobacter baumannii was significantly associated with the increased usage of extended - spectrum cephalosporins ( Pearson' s correlation coefficient,γ = 0. 785,P ＜ 0. 01 ) and carbapenems (γ = 0. 737, P ＜ 0. 01 ) . Conclusion This 6 -year study in a hospital demonstrated significant changes in antimicrobial use, which may have affected antimicrobial resistance in certain Gram -negative bacteria at the hospital.关键词
抗菌药/耐药率/革兰阴性菌Key words
antimicrobial use/ antimicrobial resistance/ gram -negative bacteria分类
医药卫生引用本文复制引用
陈勇川,彭永富,张成,蔡永青,熊丽蓉,谢林利,夏培元..回顾性分析本院抗菌药使用与G-菌耐药率变化的相关性[J].中国临床药理学杂志,2011,27(4):272-275,4.
