中国临床药理学杂志2011，Vol.27Issue(4)：283-286,4.
左旋氨氯地平对自发性高血压大鼠胸主动脉重构及内皮功能的影响
Effects of S(-) - amlodipine on thoracic aorta remodeling and endothelial function in spontaneously hypertensive rats
王睿 1吕吉元 1张明升 2刘宇 2李洁 2宋俊丽 2张文静2
作者信息
- 1. 山西医科大学第一医院心内科,太原030001
- 2. 山西医科大学药理学教研室,太原030001
- 折叠
摘要
Abstract
Objective To investigate whether S ( - ) - amlodipine can improve vascular remodeling and vascular endothelial relaxation of spontaneously hypertensive rats (SHR).Methods SHRs were randomly divided into 2 groups: hypertension control group and S ( - ) - amlodipine group.Age- matched Wistar- Kyoto (WKY) rats served as normal control group.After being treated for 12 weeks, rats were studied to observe the endothelium dependent relaxation of thoracic aorta to aeetyleholine (ACh) and sodium nitmpruside (SNP).The average media thickness (MT) and cross -sectional area (CSA) were calculated.Serum nitric oxide(NO) level was measured.Results The maximal endothelium dependent relaxation to ACh was enhanced markedly after treatment with S (-) -amlodipine, (48.39±14.86)％ vs (34.71 ±9.23)％, P=0.03.Compared with hypertension control group, MT and CSA in S( - ) - amlodipine group decreased significantly (P ＜ 0.05).Serum NO concentration were increased in S( - ) - amlodipine group (P ＜0.05).Conclusion S ( - ) -amlodipine could improve endothelial relaxation and vascular remodeling in SHR.This effect may be related to an increased release of NO.关键词
自发性高血压大鼠/内皮功能/左旋氨氯地平Key words
spontaneously hypertensive rats/ endothelial function/ S ( - ) - amlodipine分类
医药卫生引用本文复制引用
王睿,吕吉元,张明升,刘宇,李洁,宋俊丽,张文静..左旋氨氯地平对自发性高血压大鼠胸主动脉重构及内皮功能的影响[J].中国临床药理学杂志,2011,27(4):283-286,4.
