东南大学学报（自然科学版）2011，Vol.41Issue(2)：393-399,7.DOI:10.3969/j.issn.1001-0505.2011.02.034
可吸入颗粒污染物在下呼吸道运动和沉积规律的数值模拟
Simulation on movement and deposition of inhalable contaminant particles in lower respiratory tract
摘要
Abstract
A comprehensive three-dimensional numerical pulmonary model of generation 5 to 8 based on Weibel's model was developed to study the gas/solid flow behaviors in a pulmonary airway affected by chronic obstructive pulmonary disease (COPD), a high morbidity lung disease of which the patients suffer from respiratory difficulty caused by narrowed airway. The gas phase was modeled with κ-ε turbulence computational fluid dynamics (CFD) model and the particle phase was modeled with discrete particle model (DPM). Computational gas-solid flow behaviors in a three-generation airway have been compared and validated with experiments. The gas/solid flow behaviors in airway with generation 7 affected by COPD under steady and unsteady inhalation and standard airway under unsteady inhalation were simulated, and the particle deposition patterns and deposition efficiencies (DEs) were also analyzed under breathing intensity of 30, 60 and 90 L/min. It is found that the obstruction in airway may decrease the deposition area of higher and lower generations and increase the area of opposite generation through the comparison. And it also may lower the DEs of higher generation on the same side and lower generation, and raise the DEs of opposite generations and lateral generation of the same side. More particles would deposit on the constricted generation and thus the obstructed generation may become narrower.关键词
慢性阻塞性肺病/下呼吸道/颗粒沉积/沉积形式/沉积率Key words
COPD ( chronic obstructive pulmonary disease)/ lower respiratory tract/ particle deposition/ deposition pattern/ deposition efficiency分类
资源环境引用本文复制引用
陈晓乐,钟文琪,金保异..可吸入颗粒污染物在下呼吸道运动和沉积规律的数值模拟[J].东南大学学报（自然科学版）,2011,41(2):393-399,7.基金项目
国家重点基础研究发展计划(973计划)资助项目(2010CB732206)、新世纪优秀人才支持计划资助项目(NCET09-0300)、全国优秀博士学位论文资助项目(201040)、东南大学优秀青年教师基金资助项目. （973计划）
