山东医药2011，Vol.51Issue(23)：23-24,2.
HBsAg及AFP在肝细胞癌组织中的表达及其相关性
Expression of HBsAg and AFP in hepatocellular carcinoma and its correlationship
摘要
Abstract
Objective To investigate the roles of HBV infection in the pathogenesis of hepatocellular carcinoma (HCC).Methods The expression of HBsAg and alpha fetoprotein ( AFP ) in 40 cases of HCC, adjacent liver tissue specimens and 6 normal liver tissue was detected by the immunohistochemical SP method.Results The expression of HBsAg and AFP were both negative in the normal liver tissue.The positive rate of AFP in the HCC and adjacent liver tissue specimens were 70％ and 90％ ( P ＜ 0.05 ), the positive rate of HBsAg were 87.5％ and 82.5％ ( P ＞ 0.05 ); in HCC and adjacent liver tissue, AFP positive rate of HBsAg-positive patients was significantly higher than that of HBsAg-negative patients(P ＜0.05).Conclusion HBV infection may involve the pathogenesis of HCC by inducing liver cells to produce AFP.关键词
肝细胞癌/乙肝病毒表面抗原/甲胎蛋白/免疫组化Key words
hepatocellular carcinoma/ hepatitis B virus surface antigen/ alpha fetoprotein/ immunohistochemical分类
医药卫生引用本文复制引用
苏士珂,潘雷,孟凡迎,代学强,周旭..HBsAg及AFP在肝细胞癌组织中的表达及其相关性[J].山东医药,2011,51(23):23-24,2.基金项目
山东省优秀中青年科学家科研奖励基金资助项目(2007BS03038) （2007BS03038）
山东省自然科学基金资助项目 (2008C22). （2008C22）
