哈尔滨商业大学学报（自然科学版）2011，Vol.27Issue(2)：129-132,4.
胡黄连苦苷Ⅰ大鼠药动学及血浆蛋白结合率研究
Pharmacokinetics of picroside Ⅰ in rats in vivo and determination of plasma protein binding rate
摘要
Abstract
To establish a HPLC - UV method for determining picroside Ⅰ in rat plasma and study pharmacokinetics characteristic in rat in vivo, determine plasma protein binding rate.The supernatant was determined directly after the protein in plasma sample was precipitated by acetonitrile.Dikma Diamonsil (R) C18 was seleted, methanol -water - acetic acid mixture was used as mobile phase, the detective wavelength at 282 nm, the flow rate at 1.0 mL/ min.The concentration -time data were processed by 3p97 pharmacokinetics software.Picroside Ⅰ can be fitted to two -compartment model after iv administrated.Picroside Ⅰ was distributed and metabolism quickly and eliminated soon.关键词
胡黄连苦苷Ⅰ/药代动力学/血浆蛋白结合率Key words
picroside Ⅰ/ pharmacokinetics/ plasma protein binding rate分类
医药卫生引用本文复制引用
高宏伟,刁磊,匡海学,阎雪莹..胡黄连苦苷Ⅰ大鼠药动学及血浆蛋白结合率研究[J].哈尔滨商业大学学报（自然科学版）,2011,27(2):129-132,4.基金项目
国家自然科学基金项目(30600804). （30600804）
