摘要
Abstract
This paper discussed ginsenoside Rb1 ' s internal pharmacokinetic feature and relative bioavailability in compound tablets so as to acquire pharmacokinetic parameters as a reference for clinical application. Two groups of rats were poured in the Yinaokang tablet injectable suspension and an extract in notoginseng, radix panacis quinquefolii, the blood sample was adopted at different times. Determined plasma concentration with the HPLC, and obtained pharmacokinetic parameters through the 3p97 pharmacokinetic software's automatically fitting data. After the rat' s intragastric administration, filling the stomach with Yinaokang tablet powder and an extract in radix panacis quinquefolii, (the dose equals to ginsenoside Rb190 mg/kg), ginsenoside Rb1 ' s pharmacokinetic behaviors accord with one - compartment model. Pharmacokinetic parameters of the group of rats, which were filled stomachs with Yinaokang tablet, was Ka =22. 217 4 h-1 ,t1/2ka =0. 031 1 h, Ke =0. 144 5h-1, t1/2ke =4. 797 9 h, AUC =666. 175 2(μg/mL) · h pharmacokinetic parameters of the group of rats which were filled stomachs with medicinal materials was Ka =5. 428 9 h -1 , t1/2ka =0. 127 6 h, Ke =0. 134 8 h-1, t1/2ke =5. 141 3 h, AUC =622. 526 0 (μg/mL) · h. 107% relative bioavailability of ginsenoside Rb1 in Yinaokang tablets was obtained by pharmacokinetic parameters. Pharmacokinetics and relative bioavailability experiment indicate that ginsenoside Rb1 in Yinaokang tablets can distribute quickly, whereas the speed of metabolism and elimination was relatively slow. Relative bioavailability of glucoside Rb1 was very high.关键词
益脑康片/人参皂苷Rb1/药代动力学/相对生物利用度Key words
Yinaokang tablet/ ginsenoside Rb1/ pharmacokinetics/ relative bioavailability分类
医药卫生
